Dr. Anna Wenning’s (Principal Investigator) TOPANC study addresses a critical question in pancreatic surgery: for patients at high risk of postoperative pancreatic fistula, does removing the entire pancreas improve outcomes compared with partial removal and closure of the remaining pancreas?

In 2025, the DCR PPI team collaborated on the development of an explanatory video to help potential participants understand the study’s purpose and rationale before making an informed decision about participation. Patient and public involvement (PPI) contributors were actively engaged, reviewing the script and participating in the filming process.

By presenting the study in a clear and accessible way, the video aims to foster better understanding, support informed consent, and facilitate recruitment, ensuring that patients are fully equipped to make decisions about their involvement.

​

In future, the DCR will support the conduct in different areas. Monitoring, for example,  will support the study through both on-site and centralized activities. Planned measures include site initiation visits and risk-based monitoring visits, complemented by centralized data monitoring (CDM), to ensure high data quality, protocol adherence, and patient safety throughout the study.